4100 Acetaminophen

Components
NAME METHOD REFERENCE RANGE UNITS
Acetaminophen FPIA  10 - 30  ug/mL 


Specimen Requirements
TYPE VOLUME TEMPERATURE INSTRUCTIONS
PRIMARY
1 Serum 0.5 (0.3) mL   Ambient - 7 Day(s), Refrigerated - 7 Day(s), Frozen - 7 Day(s)  


Clinical utility
Acetaminophen is one of several popular non-prescription pain relievers available to the public. It has analgesic and antipyretic effects like aspirin, but little of aspirin's anti-inflammatory properties. Serum levels are not typically monitored during therapeutic dosing (650-1000 mg), but because the drug is sold along or in combination with other compounds in over two hundreds products, acetaminophen is frequently seen in overdose cases. Proper management of acetaminophen overdose requires early monitoring of the patient's serum levels, because toxic drug levels can cause hepatic necrosis, which is not clinically evident until twelve or more hours after ingestion; moreover, antidotes are available that can prevent liver damage, if they are administered early.


Reported: Same day

CPT Code: 82003

Notes: Toxic level: >300 ug/mL at 4 hour after ingestion or 50 ug/mL after 12 hour. Source: Textbook of clinical chemistry by Norbert W. Teitz