1139 Cystatin C

Components
NAME METHOD REFERENCE RANGE UNITS
Cystatin C NEPH  0.53 - 0.95  mg/L 


Specimen Requirements
TYPE VOLUME TEMPERATURE INSTRUCTIONS
PRIMARY
1 Serum 1 (0.8) mL   Ambient - 7 Day(s), Refrigerated - 7 Day(s), Frozen - 2 Month(s)  
ALTERNATE
  Plasma Heparinized 1 (0.8) mL   Ambient - 7 Day(s), Refrigerated - 7 Day(s), Frozen - 2 Month(s)  


Clinical utility
Cystatin C is a cysteine proteinase inhibitor. It is formed at a constant rate and freely filtered by the healthy kidney; this protein is a good marker of renal function. Serum concentrations of Cystatin C are almost totally dependent on the glomerular filtration rate (GFR). A reduction in the GFR causes a rise in the concentration of Cystatin C.


Collection Instruction
Avoid repeated freeze-thaw cycles, Lipemic samples must be clarified
by centrifugation prior to testing.


Reported: Same day

CPT Code: 82610

Notes: Cystatin C has not been shown to be affected by factors such as muscle mass and nutrition, factors which have been demonstrated to affect creatinine values. In addition, a rise in creatinine does not become evident until the GFR has fallen by approximately 50%.