1866 PAN-ANCA™ Evaluation

Components
NAME METHOD REFERENCE RANGE UNITS
ANCA Total Autoantibodies IFA/IMAGE  < 1:20  FIU 
ANCA Pattern IFA  By Report   
Myeloperoxidase Autoantibodies EIA  < 9.0  U/mL 
Proteinase-3 Autoantibodies EIA  < 3.5  U/mL 
Antinuclear Antibodies (ANA) IFA/IMAGE  <7.5  IU/mL 
ANA Pattern IFA  By Report   


Specimen Requirements
TYPE VOLUME TEMPERATURE INSTRUCTIONS
PRIMARY
1 Serum 3 (2) mL   Ambient - 48 Hour(s), Refrigerated - 7 Day(s), Frozen - 2 Month(s)  


Clinical utility
Antineutrophil cytoplasmic autoantibodies (ANCA) are a serological marker associated with vasculitis, glomerulonephritis and inflammatory bowel disease. Specifically, ANCA have been found (at frequencies ranging from 70% to 90%) in patients with active Wegener's granulomatosis, microscopic polyarteritis nodosa, and idiopathic crescentic glomerulonephritis (with manifestations ranging from kidney-limited disease to extrarenal systemic disease, including pulmonary-renal syndromes). Glomerular lesions in patients with ANCA-associated systemic vasculitis or renal-limited disease are virtually identical. Less than 10% of patients with other renal diseases are ANCA positive. ANCA may be directly involved in the pathogenesis of the vascular injury that causes the clinical manifestations in ANCA-associated disease.


Reported: Same day

CPT Code: 86021x3, 86038

Notes: If the result for ANCA Total Antibodies is 1:20 or greater, ANCA IgG, IgM and IgA Autoantibodies (Test Code 1022) may be requested.