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NAME | METHOD | REFERENCE RANGE | UNITS |
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ANCA Total Autoantibodies | IFA/IMAGE | < 1:20 | FIU |
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ANCA Pattern | IFA | By Report | |
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Myeloperoxidase Autoantibodies | EIA | < 9.0 | U/mL |
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Proteinase-3 Autoantibodies | EIA | < 3.5 | U/mL |
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Antinuclear Antibodies (ANA) | IFA/IMAGE | <7.5 | IU/mL |
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ANA Pattern | IFA | By Report |
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TYPE | VOLUME | TEMPERATURE | INSTRUCTIONS |
PRIMARY | ||||
1 | Serum | 3 (2) mL | Ambient - 48 Hour(s), Refrigerated - 7 Day(s), Frozen - 2 Month(s) |
Antineutrophil cytoplasmic autoantibodies (ANCA) are a serological marker associated with vasculitis, glomerulonephritis and inflammatory bowel disease. Specifically, ANCA have been found (at frequencies ranging from 70% to 90%) in patients with active Wegener's granulomatosis, microscopic polyarteritis nodosa, and idiopathic crescentic glomerulonephritis (with manifestations ranging from kidney-limited disease to extrarenal systemic disease, including pulmonary-renal syndromes). Glomerular lesions in patients with ANCA-associated systemic vasculitis or renal-limited disease are virtually identical. Less than 10% of patients with other renal diseases are ANCA positive. ANCA may be directly involved in the pathogenesis of the vascular injury that causes the clinical manifestations in ANCA-associated disease. |