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NAME | METHOD | REFERENCE RANGE | UNITS |
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Neuronal Nuclear (Hu) Autoantibodies CSF -IB | IB | Not detected | |
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Neuronal Nuclear (Ri) Autoantibodies CSF -IB | IB | Not detected | |
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Purkinje Cell (Yo) Autoantibodies CSF -IB | IB | Not detected |
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TYPE | VOLUME | TEMPERATURE | INSTRUCTIONS |
PRIMARY | ||||
1 | CSF | 3 (2) mL | Ambient - 48 Hour(s), Refrigerated - 7 Day(s), Frozen - 2 Month(s) |
In paraneoplastic cerebellar degeneration (PCD), a diffuse loss of cerebellar Purkinje cells signals the presence of an underlying, frequently occult, neoplasm. PCD is seen most frequently in postmenopausal women who present with sudden onset of ataxia, dysarthria or nystagmus. In women with PCD and type 1 Purkinje cell (Yo) autoantibodies (PCA-1), the associated malignancy is most often gynecologic (especially ovarian) or breast cancer. Type 1 neuronal nuclear (Hu) autoantibodies (ANNA-1) are most commonly seen in the paraneoplastic syndromes of subacute sensory neuronopathy (SSN) and paraneoplastic encephalomyelitis (PEM) associated with small-cell lung cancers (SCLC), but are also occasionally found in SSN/PEM patients who have other malignancies. Neurologic symptoms generally precede or coincide with the detection of a tumor in SSN/PEM. Type 2 neuronal nuclear (Ri) autoantibodies are associated with opsoclonus-myoclonus syndrome and often seen in cases of breast cancer, small cell lung cancer and gynecologic cancer. |