1187 Purkinje Cell Cytoplasmic (Yo) Autoabs

Components
NAME METHOD REFERENCE RANGE UNITS
Purkinje Cell (Yo) Autoantibodies -IB IB  Not detected   


Specimen Requirements
TYPE VOLUME TEMPERATURE INSTRUCTIONS
PRIMARY
1 Serum 2 (1) mL   Ambient - 48 Hour(s), Refrigerated - 7 Day(s), Frozen - 2 Month(s)  


Clinical utility
In paraneoplastic cerebellar degeneration (PCD), a diffuse loss of cerebellar Purkinje cells signals the presence of an underlying, frequently occult, neoplasm. PCD is seem most frequently in postmenopausal women who present with sudden onset of ataxia, dysarthria or nystagmus. In women with PCD and type 1 Purkinje cell (Yo) autoantibodies (PCA-1), the associated malignancy is most often gynecologic (especially ovarian) or breast cancer.


Reported: Same day

CPT Code: 84181

Notes: See also Paraneoplastic Syndrome Evaluation, #1171.