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4834 Voltage-Gated Calcium Channel IgG Autoantibodies

Components

	NAME	METHOD	REFERENCE RANGE	UNITS
	Voltage-gated Calcium Channel IgG Autoabs	RIA	Not detected

Specimen Requirements

	TYPE	VOLUME	TEMPERATURE	INSTRUCTIONS
PRIMARY
1	Serum	2 (1.5) mL	Ambient - 7 Day(s), Refrigerated - 14 Day(s), Frozen - 2 Month(s)

Clinical utility

Voltage-gated calcium channel (VGCC) autoantibodies are characteristic of Lambert-Eaton Myasthenic Syndrome (LEMS) with or without small-cell lung cancer. VGCC autoantibodies are also found, albeit less frequently and generally in low amounts, in paraneoplastic disease associated with lung, ovarian or breast carcinomas; in carcinomas (without LEMS or other paraneoplastic syndrome) and occasionally in neurological diseases such as amyotrophic lateral sclerosis (frequency of ~23%). This assay detects P-type VGCC autoantibodies using omega-conotoxin M toxin (omega-conotoxin MVIIC).

Reported: Same day

CPT Code: 83519