Elevations occur in gout, renal disease with renal failure, dehydration, diuretic use, alcoholism, lead poisoning, lymphoma, leukemia, infectious mononucleosis, acute inflammatory state, acidosis. Used as an indicator of renal vascular involvement in essential hypertension. Elevated uric acid may also be the result of massive nucleic acid catabolism such as occurs in toxemia of pregnancy and chemotherapy or radiation therapy of tumors. Causes of low uric acid include Wilson's disease, Fanconi syndrome, obstructive biliary disease, and syndrome of inappropriate secretion of antidiuretic hormone.
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