1155 Cryoglobulins reflex to Cryoprecipitate Immunoglobulins

Components
NAME METHOD REFERENCE RANGE UNITS
Cryoglobulin 72 hours INSP  Not detected   
Cryoglobulin 7 days INSP  Not detected   
Cryoprecipitate IgG NEPH  < 1.0  mg/dL 
Cryoprecipitate IgM NEPH  < 1.0  mg/dL 
Cryoprecipitate IgA NEPH  < 1.0  mg/dL 
Cryoprecipitate RF NEPH  < 20  IU/mL 
IFE on Cryoprecipitate AE     


Specimen Requirements
TYPE VOLUME TEMPERATURE INSTRUCTIONS
PRIMARY
1 Serum 5 (3) mL   Ambient - 72 Hour(s), Refrigerated - 72 Hour(s), Frozen - 31 Day(s) See COLLECTION INSTRUCTIONS. 


Clinical utility
Cryoglobulins may be present in macroglobulinemia of Waldenstrom, myeloma, chronic lymphocytic leukemia, lupus, chronic active hepatitis, and other viral infections.


Collection Instruction
Immediately after collection, continuously maintain vacutainer
tube at 37 C for 1 hr, followed by centrifugation maintaining 37 C.
Transfer serum to a plastic vial. Once serum is separated
from clot, it may be sent ambient, refrigerated, or frozen.


Reported: 7 days

CPT Code: 82595

Notes: If cryoglobulin is present, Cryoprecipitate is tested for IgG, IgM, IgA, RF and IFE for an additional fee. Add 2 to 4 days to turnaround time.