4929 Clorazepate (Tranxene®)

Components
NAME METHOD REFERENCE RANGE UNITS
Nordiazepam HPLC  100 - 500  ng/mL 


Specimen Requirements
TYPE VOLUME TEMPERATURE INSTRUCTIONS
PRIMARY
1 Serum 2 (1) mL   Refrigerated - 7 Day(s), Frozen - 2 Month(s) See COLLECTION INSTRUCTIONS. 
ALTERNATE
  Plasma ACD 2 (1) mL   Refrigerated - 7 Day(s), Frozen - 2 Month(s)  
  Plasma EDTA 2 (1) mL   Refrigerated - 7 Day(s), Frozen - 2 Month(s)  


Clinical utility
Orally administered clorazepate is rapidly decarboxylated to its metabolite, nordiazepam. There is essentially no circulating patent drug. Nordiazepam elimination half-life is about 40 to 50 hours. Plasma levels of nordiazepam increase proportionally with Clorazepate dose and show moderate accumulation with repeated administration.


Collection Instruction
Serum separator tubes are not acceptable; use polypropylene tubes.


Reported: Same day

CPT Code: 80154

Notes: Assayed as its primary metabolite, Nordiazepam.