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NAME | METHOD | REFERENCE RANGE | UNITS |
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Glucose-6-Phosphate Dehydrogenase | KS | 7 - 20 | U/g Hb |
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TYPE | VOLUME | TEMPERATURE | INSTRUCTIONS |
PRIMARY | ||||
1 | Whole Blood EDTA | 7 (2) mL | Refrigerated - 4 Day(s) | |
ALTERNATE | ||||
Whole Blood EDTA Microtai | 7 (2) mL | Refrigerated - 4 Day(s) |
A deficiency of G-6-PDH (glucose-6-phosphate dehydrogenase) causes hemolytic anemia. This sex-linked genetic defect involves approximately 2-3% of the world population. It is characterized by deficient concentrations of G-6-PD in erythrocytes but normal levels in leukocytes and platelets. These individuals develop hemolysis on exposure to a number of drugs and other stresses, including various infections. A severe form of G-6-PD deficiency, characterized by deficiency in leukocytes and erythrocytes is seen in Caucasians, American Indians, and Asians. Deficiency is related to the inability to maintain adequate levels of reduced glutathione in erythrocytes on exposure to offending agents. |